Muscular endurance is essential to each stroke of your stick as well as each repetition of your bass pedal (Drumming is very very repetitive!)  Using proper technique and rebound to play more efficiently will reduce the workload and strain on your body.  Drums and cymbals are inanimate objects that require the player to provide muscular force to elicit sound, the larger the volume, the more force is required.  With each and every action there is an equal and opposite reaction which drives a vibration forces into your body.  Heavy hitters experience much higher levels of stress to their muscles and bones creating more trauma to the body.  Inflammation is created from playing which may cause pain and swelling especially around your joints.  Many players complain of wrist, elbow, shoulder and back pain which typically gets worse over time, “No Pain - No Gain” usually ends your playing career earlier than you would like.  Improving technique (loosened grip on sticks especially) and ergonomics help to reduce wear and tear on your body.  Fatigue while playing can come from many sources including dehydration, depleted energy stores and a lack of conditioning and rest.